Category: Science

Testing the Capacity to Over-Stabilize Viruses by Engineering Mutations into the Capsid of Bacteriophage ɸX174

An effective virus must successfully attach to a receptor on a host cell and inject its genetic material into the cell so that new viruses can be produced. Its ability to infect the host cell is highly dependent on both the binding capability of its capsid proteins as well their ability to modify their conformation …

Expression Staining to Qualify Presence of Dscam Expression

Gene Mutations Involved in Brain Development and Autism Spectrum Disorders

Autism Spectrum Disorder (ASD) is a developmental disability characterized by sensory and communication deficits. Recently, diagnosis of ASD has increased, and it is now estimated to affect 1 in 68 children. The symptoms of autism begin to appear during the first three years of life, which coincides with the development of learning ability and a …

LAMP-OSD Assay for Insect-Borne Diseases

Abstract The distribution of vector-borne diseases such as Zika virus continues to expand, leading to epidemics across a variety of geographical locations, but monitoring the spread of these diseases for public health purposes is made difficult by a lack of instrumentation. With the assay we are developing and testing, there is no need for special …

Using Exoplanets to Study Planet Formation

Observations of exoplanets, planets outside of our solar system, have exploded in the last 20 years, to the point where we know now of thousands of exoplanet systems. One of the great mysteries to come out of these discoveries has been the great diversity in types of planetary systems seen. Up until we started discovering …

Genomic Diversity and Evolution of Succinea Land Snails in the Galápagos Archipelago

The Galápagos Islands are home to many diverse species, but not all have diverged as extensively as Darwin’s finches. What could be preventing diversification in the Succinea land snails?

A novel approach to fight a drug resistant fungal pathogen

The initial discovery We are investigating the potential of protein toxins naturally produced by Saccharomyces cerevisiae (Brewer’s/Baker’s yeast) to inhibit the growth of the human pathogen Candida glabrata. These toxin producers are known as killer yeasts to those who study them. We have tested over 15,0000 interactions between our killer yeasts and 130 isolates of …

Microbial Viability Within Hydrogel Matrices

By improving current bioremediation techniques for the removal of trichloroethylene from groundwater we can improve efficiency, improve safety, and treat spills closer to the source.

Evaluating β-Catenin as a Potential Regulator of Tenogenic Stem Cell Differentiation

Tendons are collagen-rich musculoskeletal tissues that function to anchor muscle to bone, and transfer mechanical force between the two. Unfortunately, tendon injuries are common and tendons have poor self-healing capacity, resulting in long-term dysfunction. There are few treatment options, motivating the need for engineered tendon replacements and regenerative therapies using stem cells. However, there is …

When to vaccinate a fluctuating wildlife population: is timing everything?

Investigating whether or not timing a vaccination program can help protect wildlife and potentially facilitate pathogen elimination.